Supplements Beyond Biotin: What Actually Works

Evidence-based supplement guide. Vitamin D, iron/ferritin, zinc, omega-3s, and what to skip. Science over marketing.

Comprehensive Guide | Updated December 2024 | 9 min read

Walk into any pharmacy and you'll see dozens of "hair vitamins" promising dramatic regrowth. Most are overpriced marketing with minimal science.

This guide cuts through the BS and identifies what actually matters.

The Supplements Worth Taking

1. Vitamin D3 (If Deficient)

Evidence: Vitamin D receptors regulate hair follicle cycling. Deficiency impairs anagen phase.

Target level: 40-60 ng/mL (test first)

Dose if deficient: 2,000-5,000 IU daily

Cost: $10-15 for 3-month supply

2. Iron/Ferritin (If Deficient)

Evidence: Low ferritin is #1 nutritional cause of hair shedding in men

Target level: Ferritin 40-60 ng/mL

Dose if deficient: Work with doctor (excess iron is dangerous)

Test first—don't guess

3. Omega-3 (EPA/DHA)

Evidence: Reduces systemic inflammation, supports scalp health

Dose: 2g combined EPA/DHA daily

Best source: Fatty fish 2-3x weekly OR quality fish oil supplement

Cost: $15-30/month

4. Zinc (If Deficient)

Evidence: Supports protein synthesis and cell division in follicles

Dose: 11mg daily (don't exceed 40mg—excess worsens shedding)

Get from food first: Oysters, beef, pumpkin seeds

Only supplement if tested deficient

Supplements to Skip

❌ Biotin (Unless Deficient)

Why skip: Biotin deficiency is rare. Supplementing beyond deficiency doesn't boost growth. See our biotin deep dive.

Exception: If blood test shows deficiency

❌ Collagen Supplements

Why skip: Weak evidence for hair specifically. Your body breaks down collagen into amino acids anyway—just eat protein.

❌ "Hair Vitamins" with Proprietary Blends

Why skip: Overpriced, under-dosed active ingredients hidden in "blends", marketing > science

The One Supplement Worth Considering: Nutrafol

Cost: $79/month

Evidence: 2023 RCT showed 79% improvement vs 51% placebo at 6 months

Contains: Saw palmetto, ashwagandha, curcumin, marine collagen, biotin, more

Best for: Men wanting natural DHT-blocking approach who can afford it

Reality check: Less effective than finasteride (38% improvement vs 68% for finasteride in studies), but may work for mild thinning

🔬 The Evidence Hierarchy

Tier 1 (proven): Finasteride, Minoxidil, Hair Transplant

Tier 2 (some evidence): Nutrafol, Saw Palmetto, Pumpkin Seed Oil

Tier 3 (minimal evidence): Most "hair vitamins", Biotin, Collagen

The Cost-Benefit Analysis

SupplementAnnual CostEvidence Level
Vitamin D$40Strong (if deficient)
Omega-3$180-360Moderate
Nutrafol$948Moderate
Generic Finasteride$240Very Strong
Minoxidil$360Very Strong

Notice: Finasteride + minoxidil ($600/year) costs less than Nutrafol alone and has far stronger evidence.

Skip Overpriced Supplements—Get Proven Treatments

Supplements are fine as adjuncts, but finasteride + minoxidil have 30+ years of clinical evidence. Start with what works.

Start Finasteride + Minoxidil →

The Smart Supplement Strategy

1. Test first: Get bloodwork for Vitamin D, ferritin, possibly zinc
2. Supplement deficiencies: Target low levels with appropriate doses
3. Add omega-3: If not eating fatty fish regularly
4. Consider Nutrafol: Only if budget allows AND you want natural approach
5. Skip everything else: Marketing fluff

Most important: Supplements support but don't replace finasteride/minoxidil.

Next Steps